Activin receptor-like kinase (ALK)

激活素受体样激酶

英文解释

Activin receptor-like kinase (ALK)is the type I receptor of transforming growth factor-β (TGF-β) superfamily. Phosphorylated ALK activates multiple downstream signal transduction pathways, including MAPK-ERK, PI3K-AKT, PLCγ, CRKL-C3G, and JAK-STAT.

中文解释

激活素受体样激酶 (ALK) 是转化生长因子 β (TGF-β) 超家族的 I 型受体。磷酸化的ALK激活多种下游信号转导途径，包括 MAPK-ERK，PI3K-AKT，PLCγ，CRKL-C3G 和 JAK-STAT。

参考文献

[1]. Palmer RH, et al. Anaplastic lymphoma kinase: signalling in development and disease. Biochem J. 2009 May 27;420(3):345-61.