Adenylyl cyclase (AC)

腺苷酸环化酶

英文解释

Adenylyl cyclases (ACs) are membrane bound enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) in response to the activation by G-protein Gαs. Different isoforms of ACs are ubiquitously expressed in different tissues involved in regulatory mechanisms in response to specific stimulants.

中文解释

腺苷酸环化酶 (AC) 是膜结合酶，可响应 G 蛋白 Gαs 的激活，催化三磷酸腺苷 (ATP) 生成环磷酸腺苷 (cAMP)。ACs 的不同亚型在不同组织中普遍表达，这些组织参与响应特定兴奋剂的调节机制。

参考文献

[1]. Tatum Price, et al. Adenylyl cyclase 7 and neuropsychiatric disorders: A new target for depression? Pharmacol Res. 2019 May;143:106-112.
[2]. Appalaraju Jaggupilli, et al. Study of adenylyl cyclase-GαS interactions and identification of novel AC ligands. Mol Cell Biochem. 2018 Sep;446(1-2):63-72.