AIM2-like receptors (ALRs)

AIM2 样受体

英文解释

AIM2-like receptors (ALRs) are a family of structurally related proteins. ALRs is critical in innate immunity, and determine the course of infections, inflammatory diseases, senescence, and cancer. ALRs inhibt DNA repair, thereby accelerateing genome destabilization, micronuclei generation, and cell death.

中文解释

AIM2 样受体 (ALR) 是一个结构相关的蛋白质家族。ALRs 在先天免疫中至关重要，并决定感染、炎症性疾病、衰老和癌症的进程。ALR 抑制 DNA 修复，从而加速基因组不稳定、微核生成和细胞死亡。

参考文献

[1]. Jiang H, et al. Nuclear AIM2-Like Receptors Drive Genotoxic Tissue Injury by Inhibiting DNA Repair. Adv Sci (Weinh). 2021 Nov;8(22):e2102534.