Allosteric inhibitor

别构抑制剂

英文解释

Allosteric inhibitor is a kind of compound that binds to a distinct site on the surface of the enzyme or receptor, instead of the substrate-binding domain. Allosteric inhibitor offers a advantage in designing small-molecule inhibitors for lipid-metabolizing enzymes.

中文解释

别构抑制剂是一种与酶或受体表面的不同位点结合，而不是与底物结合域结合的化合物。别构抑制剂在设计用于脂质代谢酶的小分子抑制剂方面具有较好的优势。

参考文献

[1]. Wenthur CJ,et al. Drugs for allosteric sites on receptors. Annu Rev Pharmacol Toxicol. 2014;54:165-84.