Aminoimidazole carboxamide ribotide (AICAR)

氨基咪唑羧酰胺核苷酸

英文解释

Aminoimidazole carboxamide ribotide (AICAR) is a purine biosynthetic intermediate and a substrate of the AICAR transformylase/IMP cyclohydrolase (PurH) enzyme in Salmonella enterica. Aminoimidazole carboxamide ribotide (AICAR) accumulates and indirectly inhibits synthesis of the essential coenzyme thiamine pyrophosphate (TPP).

中文解释

氨基咪唑羧酰胺核苷酸 (AICAR)，是一种嘌呤生物合成中间体，是肠道沙门氏菌中 AICAR 转化酶/IMP 环水解酶 (PurH) 的底物。氨基咪唑羧酰胺核苷可累积并间接抑制必需辅酶硫胺焦磷酸 (TPP) 的合成。

参考文献

[1]. Bazurto JV, et al. Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica. Microb Cell. 2017 Nov 22;5(2):74-87.