Anaplastic lymphoma kinase (ALK)

间变性淋巴瘤激酶

英文解释

Anaplastic lymphoma kinase (ALK) is a Receptor protein tyrosine kinase (rPTK), a member of the insulin receptor superfamily. ALK was first described in 1994 as the NPM-ALK fusion protein that is expressed in the majority of anaplastic large-cell lymphomas.

中文解释

间变性淋巴瘤激酶 (ALK) 是一种受体蛋白酪氨酸激酶 Receptor protein tyrosine kinase (rPTK)，是胰岛素受体超家族的成员。ALK 于 1994 年首次被描述为在大多数间变性大细胞淋巴瘤中表达的 NPM-ALK 融合蛋白。

参考文献

[1]. Robert Roskoski Jr, et al. Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition. Pharmacol Res. 2013 Feb;68(1):68-94.