Base excision repair (BER)

碱基切除修复

英文解释

Base excision repair (BER) is a frontline repair system that is responsible for maintaining genome integrity and thus preventing premature aging, cancer and many other human diseases by repairing thousands of DNA lesions and strand breaks continuously caused by endogenous and exogenous mutagens.

中文解释

碱基切除修复(BER)是一种前线修复系统，通过修复内源性和外源性诱变剂引起的成千上万的 DNA 损伤和链断裂，负责保持基因组完整性，从而预防过早衰老、癌症和许多其他人类疾病。

参考文献

[1]. Grigory L Dianov, et al. Mammalian base excision repair: the forgotten archangel. Nucleic Acids Res. 2013 Apr 1;41(6):3483-90.