C-C chemokine receptor 9 (CCR9)

C-C 趋化因子受体 9

英文解释

C-C chemokine receptor 9 (CCR9) is the homing receptor for C-C motif chemokine ligand 25 (CCL25), and contributes to the maintenance of mucosal immunity and pathogenesis of Inflammatory bowel disease (IBD) through the recruitment of T cells into the gut mucosa.

中文解释

C-C 趋化因子受体 9 (CCR9)是 C-C 基序趋化因子配体 25 (CCL25) 的受体，通过将 T 细胞招募到肠道粘膜，有助于维持黏膜免疫和 Inflammatory bowel disease (IBD) 的发病机制。

参考文献

[1]. Igaki K, et al. MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model. Int Immunopharmacol. 2018 Jul;60:160-169.