c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK)

c-Jun N-末端激酶/应激激活蛋白激酶

英文解释

c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK), a major cellular stress response protein induced by oxidative stress, is a subfamily member of mitogen-activated protein kinase superfamily molecules. JNK/SAPK plays an important role in Alzheimer disease (AD).

中文解释

c-Jun N-末端激酶 (JNK)/应激激活蛋白激酶（SAPK）是一种由氧化应激诱导的主要细胞应激反应蛋白，是丝裂原激活蛋白激酶超家族分子的亚家族成员。JNK/SAPK 在 阿尔茨海默症 中发挥重要作用。

参考文献

[1]. X Zhu, et al. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem. 2001 Jan;76(2):435-41.
[2]. K Shirakabe, et al. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.