calcium/calmodulin-dependent protein kinase kinase 2, β (CAMKK2/CaMKKβ)

钙/钙调蛋白依赖性蛋白激酶激酶 2，β

英文解释

Calcium/calmodulin-dependent protein kinase kinase 2, β (CAMKK2/CaMKKβ) is a serine/threonine-directed kinase that is activated following increases in intracellular Ca2+.CaMKKβ activates Ca2+/calmodulin-dependent protein kinase I, Ca2+/calmodulin-dependent protein kinase IV, and the AMP-dependent protein kinase in a number of physiological pathways, including learning and memory formation, neuronal differentiation, and regulation of energy balance.

中文解释

钙/钙调蛋白依赖性蛋白激酶激酶 2，β (CAMKK2/CaMKKβ) 是一种丝氨酸/苏氨酸导向的激酶，在细胞内 Ca2+ 增加后被激活。CaMKKβ 激活 Ca2+/钙调素依赖的蛋白激酶 I，Ca2+/钙调素依赖的蛋白激酶 IV 和 AMP 依赖的蛋白激酶，包括学习和记忆形成，神经元分化和能量平衡调节。

参考文献

[1]. Green et al. Ca2+/Calmodulin-dependent protein kinase kinase beta is regulated by multisite phosphorylation. J Biol Chem. 2011 Aug 12;286(32):28066-79.