Calpains

钙蛋白酶

英文解释

Calpains are a group of non-lysosomal Ca2+-dependent cysteine proteases with numerous substrates. Calpains have been identified in almost all eukaryotes and bacteria.In the human genome, this group of enzymes has 15 isoforms and is present ubiquitously and demonstrates tissue-specific patterns of expression. Calpains are involved in different physiological and pathological processes such as cell proliferation, migration, invasion, apoptosis and signal transduction and their roles in various disorders have been reported.

中文解释

钙蛋白酶 (Calpain) 是一组非溶酶体 Ca2+ 依赖性半胱氨酸蛋白酶具有众多底物。钙蛋白酶几乎存在于所有真核生物和细菌中。在人类基因组中，这种酶有15种亚型，普遍存在，并表现出组织特异性的表达模式。钙蛋白酶参与细胞增殖、迁移、侵袭、凋亡和信号转导等不同的生理和病理过程，在多种疾病中的作用已被报道。

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