Cellular inhibitor of apoptosis proteins (CIAPs)

细胞凋亡抑制蛋白

英文解释

Cellular inhibitor of apoptosis proteins (CIAPs) are essential RING E3 ubiquitin ligases that regulate apoptosis and inflammatory responses. cIAPs contain a ubiquitin-associated (UBA) domain that binds ubiquitin and is implicated in the regulation of cell survival and proteasomal degradation.

中文解释

细胞凋亡抑制蛋白 (CIAPs) 是调控细胞凋亡和炎症反应的重要环 E3 泛素连接酶。cIAPs 含有一个泛素相关 (UBA) 结构域，该结构域与泛素结合，并与调节细胞存活和蛋白酶体降解有关。

参考文献

[1]. Budhidarmo R, Day CL. The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. J Biol Chem. 2014 Sep 12;289(37):25721-36.