Chimeric antigen receptor (CAR)

嵌合抗原受体

英文解释

Chimeric antigen receptor (CAR) is a genetically recombinant receptor that can be transduced to different immune cells, such as NK cells and T lymphocytes. The CAR redirects the specifcity of the T/NK cell against a specifc antigen on tumor cells. CAR can identify diverse target antigens including carbohydrates, proteins, glycolipids, etc.

中文解释

嵌合抗原受体 (CAR) 是一种基因重组受体，可以转导到不同的免疫细胞，如 NK 细胞和 T 淋巴细胞。CAR 重定向 T/NK 细胞对肿瘤细胞上特定抗原的特异性。CAR-CAR 可以识别多种目标抗原，包括碳水化合物、蛋白质、糖脂等。

参考文献

[1]. Elahi R, et al. Chimeric Antigen Receptor-Engineered Natural Killer (CAR NK) Cells in Cancer Treatment; Recent Advances and Future Prospects. Stem Cell Rev Rep. 2021 Dec;17(6):2081-2106.