Collagen

胶原蛋白

英文解释

Collagen is the most abundant proteins in mammals. The collagen family comprises 28 members that contain at least one triple-helical domain. Collagens are deposited in the extracellular matrix where most of them form supramolecular assemblies. Four collagens are type II membrane proteins that also exist in a soluble form released from the cell surface by shedding. Collagens play structural roles and contribute to mechanical properties, organization, and shape of tissues. They interact with cells via several receptor families and regulate their proliferation, migration, and differentiation. Some collagens have a restricted tissue distribution and hence specific biological functions.

中文解释

胶原蛋白 (Collagen) 是哺乳动物中含量最多的蛋白质。胶原蛋白家族包括 28 个成员，其中至少包含一个三螺旋结构域。胶原蛋白沉积在细胞外基质中，其中大多数形成超分子组合。四种胶原蛋白是 II 型膜蛋白，也以可溶性形式存在，通过脱落从细胞表面释放。胶原蛋白发挥结构作用，并有助于机械性能，组织和组织的形状。它们通过几个受体家族与细胞相互作用，并调节细胞的增殖、迁移和分化。有些胶原蛋白的组织分布受限，因此具有特定的生物学功能。

参考文献

[1]. Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a004978.