Cyclic nucleotide phosphodiesterases (PDEs)

环核苷酸磷酸二酯酶

英文解释

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They are critical regulators of the intracellular concentrations of cAMP and cGMP as well as of their signaling pathways and downstream biological effects.

中文解释

环核苷酸磷酸二酯酶(PDEs)是一种通过催化cAMP和GMP水解来终止环核苷酸信号的独特酶。它们是细胞内cAMP和cGMP浓度及其信号通路和下游生物效应的关键调节因子。

参考文献

[1]. Monalisa F Azevedo, et al. Clinical and molecular genetics of the phosphodiesterases (PDEs). Endocr Rev. 2014 Apr;35(2):195-233.