Cyclophilin A (CypA)

亲环素 A

英文解释

Cyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly expressed isozyme of the 18 known human cyclophilins. Besides acting as an intracellular receptor for cyclosporine A, CypA plays a vital role in microorganismal infections, cardiovascular diseases, liver diseases, kidney diseases, neurodegeneration, cancer, rheumatoid arthritis, periodontitis, sepsis, asthma, and aging.

中文解释

亲环素 A (CypA) 是亲免疫素家族的关键成员，是已知的 18 种人类亲环素中表达最多的同工酶。除了作为环孢素A的细胞内受体外，CypA 在微生物感染、心血管疾病、肝脏疾病、肾脏疾病、神经退行性变、癌症、类风湿性关节炎、牙周炎、败血症、哮喘和衰老中起着至关重要的作用。

参考文献

[1]. Liao Y, et al. Cyclophilin A: a key player for etiological agent infection. Appl Microbiol Biotechnol. 2021 Feb;105(4):1365-1377.