Disruptor of telomeric silencing 1-like (DOT1L)

英文解释

Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase, which catalyzes mmethylation of H3K79me. DOT1L is associated eith chromatin-associated functions, such as gene transcription, heterochromatin formation, and DNA repair.

中文解释

Disruptor of telomeric silencing 1-like (DOT1L) 是一种非 SET 结构域，其含有甲基转移酶。DOT1L 可催化 H3K79me 的甲基化。DOT1L 与染色质相关功能有关，例如基因转录、异染色质形成和 DNA 修复。

参考文献

[1]. Kari V, et al. The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness. Clin Epigenetics. 2019 Jan 7;11(1):4.