DNA damage response (DDR)

DNA 损伤反应

英文解释

DNA damage response (DDR) is a complex signal transduction pathway that has the ability to sense DNA damage and transduce this information to the cell to influence cellular responses to DNA damage. DNA damage response (DDR) is involved in regulation of metabolic homeostasis including promoting cell death or senescence, inducing tissue inflammation.

中文解释

DNA 损伤反应 (DDR) 是一种复杂的信号转导途径，能够感知 DNA 损伤，并将这一信息转导到细胞，从而影响细胞对 DNA 损伤的反应。DNA 损伤反应参与调节代谢稳态，包括促进细胞死亡或衰老，诱导组织炎症。

参考文献

[1]. Ciccia A, et al. The DNA damage response: making it safe to play with knives. Mol Cell. 2010 Oct 22;40(2):179-204.
[2]. Shimizu I, et al. DNA damage response and metabolic disease. Cell Metab. 2014 Dec 2;20(6):967-77.