Dual leucine zipper kinase (DLK)

双亮氨酸拉链激酶

英文解释

Dual leucine zipper kinase (DLK) is a serine/threonine protein kinase that is a member of the mixed lineage kinase subfamily. Dual leucine zipper kinase (DLK) isresponsible for activating JNK and mediating the apoptotic stress response in various cell types, specifically neurons.Dual leucine zipper kinase (DLK)inhibition shows neuroprotective effects in cellular and animal models of Alzheimer's disease, glaucoma, Parkinson's disease and other Neurodegenerative diseases (NDDs).

中文解释

双亮氨酸拉链激酶 (DLK) 是一种丝氨酸/苏氨酸蛋白激酶，是混合谱系激酶亚家族的成员。双亮氨酸拉链激酶负责激活JNK，介导各种细胞类型特别是神经元的凋亡应激反应。双亮氨酸拉链激酶抑制在 阿尔茨海默症、青光眼、帕金森病和其他神经退行性疾病 神经退行性疾病 的细胞和动物模型中显示出神经保护作用。

参考文献

[1]. Ferraris D, et al. Dual leucine zipper kinase as a therapeutic target for neurodegenerative conditions. Future Med Chem. 2013 Oct;5(16):1923-34.