Endoplasmic reticulum stress (ERS)

内质网应激

英文解释

Endoplasmic reticulum stress (ERS) is defined as a chronic perturbation impacting the homeostasis of ER. ERS is primarily characterized by the accumulation of aberrant proteins, which disturbs the balance of the protein folding capacity of the ER. ERS is usually induced during solid tumor development and stage progression.

中文解释

内质网应激 (ERS) 是一种影响 ER 稳态的慢性扰动。ERS 的主要特征是异常蛋白质的积累，从而扰乱了 ER 蛋白质折叠能力的平衡。ERS 通常发生在在实体瘤的发展中。

参考文献

[1]. Corazzari M,et al. Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate. Front Oncol. 2017 Apr 26;7:78.