Energy coupling factor (ECF) transporter

能量耦合因子

英文解释

Energy coupling factor (ECF) transporters are a subgroup of ATP-binding cassette (ABC) transporters involved in the uptake of vitamins and micronutrients in prokaryotes. In contrast to classical ABC importers, ECF transporters do not make use of water-soluble substrate binding proteins or domains but instead employ integral membrane proteins for substrate binding (named S-components). S-components form active translocation complexes with the ECF module, an assembly of two nucleotide-binding domains (NBDs, or EcfA) and a second transmembrane protein.

中文解释

能量耦合因子 (ECF) 转运体是 atp 结合盒 (ABC) 转运体的一个亚群，参与原核生物对维生素和微量营养素的摄取。与经典的 ABC 导入蛋白相比，ECF 转运蛋白不使用水溶性底物结合蛋白或结构域，而是使用完整的膜蛋白结合底物(命名为 s 组分)。s 组分与 ECF 模块形成活性易位复合体，ECF 模块由两个核苷酸结合结构域 (NBDs，或 EcfA) 和第二个跨膜蛋白组成。

参考文献

[1]. Guus B Erkens, et al. Energy coupling factor-type ABC transporters for vitamin uptake in prokaryotes. Biochemistry. 2012 Jun 5;51(22):4390-6.