Ephrin/Eph family

Ephrin/Eph 家族

英文解释

Ephrin/Eph family are a large family of receptors and ligands involved in organogenesis and homeostasis of adult tissues. They are extensively expressed in the thymus and seem to be involved in the colonization of lymphoid progenitor cells and their migration throughout the thymic parenchyma necessary to provide an adequate topological location of developing thymocytes in the epithelial network that ensures their correct differentiation.

中文解释

Ephrin/Eph 家族 (Ephrin/Eph family) 是一个参与成人组织器官发生和内稳态的受体和配体家族。它们在胸腺中广泛表达，似乎参与了淋巴样祖细胞的定植和它们在整个胸腺实质的迁移，这是在上皮网络中为发育中的胸腺细胞提供适当的拓扑位置所必需的，以确保它们的正确分化。

参考文献

[1]. Mu?oz JJ, et al. Eph/Ephrin-mediated interactions in the thymus. Neuroimmunomodulation. 2011;18(5):271-80.