Epidermal growth factor receptor (EGFR)

表皮生长因子受体

英文解释

Epidermal growth factor receptor (EGFR) family comprises four distinct receptors: the EGFR (ErbB-1/HER1), ErbB-2 (neu, HER2), ErbB-3 (HER3) and ErbB-4 (HER4). EGFR belongs to receptor tyrosine kinases (RTKs). EGFR signaling is a key regulator in cell proliferation, differentiation, division, survival, and cancer development.

中文解释

表皮生长因子受体 (EGFR) 家族包含四种亚型: EGFR (ErbB-1/HER1)、ErbB-2 (neu、HER2)、ErbB-3 (HER3) 和 ErbB-4 (HER4)。 EGFR 属于受体酪氨酸激酶 (RTK) 家族。 EGFR 信号通路是细胞增殖、分化、分裂、存活和癌症发展的关键调节因子。

参考文献

[1]. Sabbah DA, et al. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834.