Epithelial–mesenchymal transition (EMT)

上皮至间质转化

英文解释

Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells acquire mesenchymal phenotypes and behaviour ( lose cell polarity and cell–cell adhesion, and gain migratory and invasive properties) , thereby following the downregulation of epithelial features.

中文解释

上皮至间质转化 (EMT) 是一个细胞内的生物学过程，在此过程中上皮细胞获得间充质表型和行为（失去细胞极性和细胞-细胞粘附，并获得迁移和侵袭特性），从而减弱上皮特征。

参考文献

[1]. Yang, J., et al.Guidelines and definitions for research on epithelial–mesenchymal transition.Nat Rev Mol Cell Biol21, 341–352 (2020).