Estrogen receptor α (ER)

雌激素受体 α

英文解释

Estrogen receptor α (ER) is a ligand dependent transcription factor that directly binds specific estrogen responsive elements, thus regulating the transcription of estrogen sensitive genes.ERα has also been shown to be associated with the plasma membrane (membrane associated ERα, mERα), concentrated in lipid rafts, plasma membrane microdomains with a distinct lipid composition, where it transduces membrane-initiated estrogen-dependent activation of the Mitogen-activated protein kinase (MAPK) signaling pathway.

中文解释

雌激素受体 α (ER) 是一种配体依赖的转录因子，直接结合特定的雌激素响应元件，从而调节雌激素敏感基因的转录。ERα 也被证明与质膜相关 (膜相关 ERα，mERα)，集中在脂质泡中，具有独特的脂质成分的质膜微域，在那里它转导由膜启动的雌激素依赖性的 Mitogen-activated protein kinase (MAPK) 信号通路的激活。

参考文献