Eukaryotic translation elongation factor 2 kinase (eEF2K)

真核生物延伸因子 2 激酶

英文解释

Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual protein kinase that regulates the elongation stage of protein synthesis by phosphorylating and inhibiting its only known substrate, eEF2. eEF2K is a drug target in cancer, and in cardiovascular and neurodegenerative diseases.

中文解释

真核生物延伸因子 2 激酶 (eEF2K) 是一种蛋白激酶，它通过磷酸化和抑制其唯一已知的底物 eEF2 来调节蛋白质合成。eEF2K 是癌症、心血管和神经退行性疾病的药物靶点。

参考文献

[1]. Liu R, et al. Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases. Acta Pharmacol Sin. 2016 Mar;37(3):285-94.