Extracellular signal-regulated kinase (ERK)

细胞外信号调节激酶

英文解释

Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) and ERK2 (p42), respectively. There are also several atypical forms of ERK, including ERK3, ERK4, ERK5 and ERK7. The ERK1/2 signaling pathway has been implicated in many and diverse cellular events, including proliferation, growth, differentiation, cell migration, cell survival, metabolism and transcription.

中文解释

细胞外信号调节激酶 (ERK) 是丝裂原激活蛋白激酶家族的信号分子之一。ERK 主要有两种形式，分别是 ERK1 (p44) 和 ERK2 (p42)。ERK 也有几种非典型形式，包括 ERK3, ERK4, ERK5 和 ERK7。

参考文献

[1]. Yuzhen Niu, et al. Current developments in extracellular-regulated protein kinase (ERK1/2) inhibitors. Drug Discov Today. 2022 May;27(5):1464-1473.