Extracellular-regulated kinase 1/2 (ERK1/2)

细胞外信号调节激酶 1/2

英文解释

Extracellular signal-regulated kinase 1/2 (ERK1/2) is an important member of the Mitogen-activated protein kinase (MAPK) family, is found in many organisms, and it participates in intracellular signal transduction. Phosphorylated ERK1/2 moves to the nucleus, activates many transcription factors, regulates gene expression, and controls various physiological processes, finally inducing repair processes or cell death.

中文解释

细胞外信号调节激酶 1/2 (ERK1/2) 是 Mitogen-activated protein kinase (MAPK) 家族的重要成员，存在于许多生物体内，参与细胞内信号转导。磷酸化的 ERK1/2 进入细胞核，激活多种转录因子，调控基因表达，控制各种生理过程，最终诱导修复过程或细胞死亡。

参考文献

[1]. Kong T, et al. Role of theExtracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Ischemia-Reperfusion Injury. Front Physiol. 2019 Aug 14;10:1038.