Farnesyltransferase (FTase)

法尼基转移酶

英文解释

Farnesyltransferase (FTase) is a two-subunits heterodimeric zinc enzyme that is comprised by a 48 kDa a-subunit and a 46 kDa ?-subuni. Farnesyltransferase (FTase) is a major molecular target for the development of novel anticancer drugs that are designed to disrupt the aberrant signal transduction circuitry of tumor cells.

中文解释

法尼基转移酶 (FTase) 是一种双亚基异二聚体锌酶，由一个 48 kDa α-亚基和一个 46 kDa β-亚基组成。 法尼基转移酶 (FTase) 是开发新型抗癌药物的主要分子靶标，旨在破坏肿瘤细胞的异常信号转导电路。

参考文献

[1]. Kuichun Zhu, et al. Farnesyltransferase inhibitors as anticancer agents: current status. Curr Opin Investig Drugs. 2003 Dec;4(12):1428-35.
[2]. Sérgio F Sousa, et al. Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem. Curr Med Chem. 2008;15(15):1478-92.