First pass elimination

首过消除

英文解释

First-pass elimination: After the drug absorbed through the gastrointestinal biofilm enters the liver through the hepatic portal vein, the drug can be biotransformed under the action of liver drug enzymes. The degradation or inactivation of drugs before entering the systemic circulation is called "hepatic first-pass metabolism" or "hepatic first-pass effect". The greater the hepatic first-pass effect, the more the drug is metabolized, the lower the blood drug concentration and the drug effect will be significantly affected.

中文解释

First-pass elimination: After the drug absorbed through the gastrointestinal biofilm enters the liver through the hepatic portal vein, the drug can be biotransformed under the action of liver drug enzymes. The degradation or inactivation of drugs before entering the systemic circulation is called "hepatic first-pass metabolism" or "hepatic first-pass effect". The greater the hepatic first-pass effect, the more the drug is metabolized, the lower the blood drug concentration and the drug effect will be significantly affected.

参考文献

[1]. Jones CR, et al. Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination. AAPS J. 2016;18(3):589-604.