Fms like tyrosine kinase 3 (FLT3)

FMS 样酪氨酸激酶 3

英文解释

FMS-like tyrosine kinase 3 ( FLT3) is a receptor tyrosine kinase that is expressed almost exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. Deregulated FLT3 activity has been implicated in several diseases, including acute myeloid leukemia and autoimmune diseases.

中文解释

FMS 样酪氨酸激酶 3 (FLT3) 是一种受体酪氨酸激酶，几乎只在造血细胞中表达。 它的配体 FLT3 配体 诱导其二聚化和激活 内在的酪氨酸激酶活性。 失调的 FLT3 活性与多种疾病有关，包括急性髓性白血病和自身免疫性疾病。

参考文献

[1]. Julhash U Kazi, et al. FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications. Physiol Rev. 2019 Jul 1;99(3):1433-1466.