GABAA receptors (GABAAR)

GABAA 受体

英文解释

GABAA receptors (GABAAR) are pentameric ligand-gated chloride channels of crucial importance for the vertebrate nervous system physiology. They typically modulate the fast inhibitory neurotransmission, and represent the target receptors for major classes of drugs used in the clinic, such as benzodiazepines and general anesthetics.

中文解释

GABAA 受体 (GABAAR) 是五聚体配体门控氯离子通道，对脊椎动物神经系统生理具有重要意义。它们通常调节快速抑制性神经传递，并代表临床使用的主要药物类别的目标受体，如苯二氮卓类药物和全身麻醉剂。

参考文献

[1]. Scott S, Aricescu AR. A structural perspective on GABAA?receptor pharmacology. Curr Opin Struct Biol. 2019 Feb;54:189-197.