Glycyrrhetic acid (GA)

甘草次酸

英文解释

Glycyrrhetic acid (GA), is a constituent of liquorice. GAis a potent inhibitor of11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD), which catalyses the conversion of cortisol to the inactive steroid Cortisone (HY-17461)in man (and corticosterone to 11-dehydrocorticosterone in rodents).

中文解释

甘草次酸 (GA)，是甘草的一个组成部分。GA 是 11-羟基甾体脱氢酶的有效抑制剂，它催化皮质醇在人体内转化为不活跃的类固醇可的松 Cortisone (HY-17461) (以及皮质酮在啮齿动物体内转化为 11-脱氢皮质酮)。

参考文献

[1]. Teelucksingh S, et al. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet. 1990 May 5;335(8697):1060-3.