Histone deacetylase (HDAC)

组蛋白脱乙酰酶

英文解释

Histone deacetylase (HDAC) is a major class of deacetylation enzymes. HDAC catalyzes the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. Many HDACs exist in large protein complexes in cells and their functions strongly depend on the complex composition.

中文解释

组蛋白脱乙酰酶 (HDAC) 是一类主要的脱乙酰酶。组蛋白去乙酰化酶 催化去除组蛋白和非组蛋白赖氨酸残基中的乙酰官能团。许多 HDACs 存在于细胞内的大蛋白复合体中，其功能与复合体的组成密切相关。

参考文献

[1]. Edward Seto, et al. Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harb Perspect Biol. 2014 Apr 1;6(4):a018713.
[2]. Jianfu Zhang, et al. Identification of Histone deacetylase (HDAC)-Associated Proteins with DNA-Programmed Affinity Labeling. Angew Chem Int Ed Engl. 2020 Sep 28;59(40):17525-17532.