HMG-CoA reductase (HMGCR)

HMG-CoA 还原酶

英文解释

HMG-CoA reductase (HMGCR) is a NADPH-dependent and rate-limiting enzyme of mevalonate (MVA) pathway. And HMG-CoA reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonic acid, involves in biosynthesis of cholesterol.

中文解释

HMG-CoA 还原酶 (HMGCR) 是一种依赖于 NADPH 的甲羟戊酸 (MVA) 途径限速酶。HMG-CoA 还原酶能够催化 HMG-CoA 转化为甲戊酸，参与胆固醇的生物合成。

参考文献

[1]. Schumacher MM, et al. Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol. Annu Rev Biochem. 2021 Jun 20;90:659-679.