Homologous recombination (HR)

同源重组

英文解释

Homologous recombination (HR) is a type of genetic recombination where genetic information is exchanged between two similar or identical molecules of double-stranded or single-stranded nucleic acids. Homologous recombination is a DNA metabolic process found in all forms of life that provides repair or tolerance of complex DNA damages including DNA gaps, DNA double-stranded breaks (DSBs), and DNA interstrand crosslinks (ICLs).

中文解释

同源重组是一种遗传重组，是指遗传信息在两个相似或相同的双链或单链核酸分子之间发生交换。同源重组存在于所有生命形式中的 DNA 代谢过程，可提响应复杂 DNA 损伤而进行修复，包括 DNA 缺口、DNA 双链断裂 (DSB) 和 DNA 链交联 (ICL)等 DNA 损伤。

参考文献

[1]. Li X, et al. Homologous recombination in DNA repair and DNA damage tolerance. Cell Res. 2008 Jan;18(1):99-113.