Host-directed therapy (HDT)

宿主导向疗法

英文解释

Host-directed therapeutics, also called host targeted therapeutics, act via a host-mediated response to pathogens rather than acting directly on the pathogen. Host-directed therapeutics may limit pathogen proliferation, e.g., have bacteriostatic effects.

中文解释

宿主导向疗法 (HDT)，也称为宿主靶向疗法，通过宿主介导的对病原体的反应而不是直接作用于病原体。宿主导向疗法可以限制病原体的增殖，例如，具有抑菌作用。

参考文献

[1]. Hawn TR, Matheson AI, Maley SN, Vandal O. Host-directed therapeutics for tuberculosis: can we harness the host? Microbiol Mol Biol Rev. 2013 Dec;77(4):608-27.
[2]. Paik S, et al. Autophagy: A new strategy for host-directed therapy of tuberculosis. Virulence. 2019 Dec;10(1):448-459.