Hypoxia response elements (HREs)

缺氧反应元件

英文解释

Hypoxia response elements (HREs)is composed of 5'-TACGTG-3' sites and some variable side sequences due to the activation of HIF-1α. In the process of hypoxic transcription activation, cis-regulation is performed, which is related to angiogenesis.

中文解释

缺氧反应元件 (HREs)，由于活化后的 HIF-1α 相结合的 5’-TACGTG-3’ 位点和一些易变旁侧序列组成。在低氧转录激活过程中，进行顺式调控，与血管内皮生成相关。

参考文献

[1]. Slemc L, et al. Transcription factor HIF1A: downstream targets, associated pathways, polymorphic hypoxia response element (HRE) sites, and initiative for standardization of reporting in scientific literature. Tumour Biol. 2016 Nov;37(11):14851-14861.