Immune checkpoint inhibitors (ICIs)

免疫检查点抑制剂

英文解释

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that antagonize immune inhibitory pathways known as checkpoints. The most widely used ICIs are anti CTLA-4, anti Programmed death receptor 1 (PD-1), and anti Programmed cell death ligand 1 (PD-L1) antibodies. These drugs are not thought to be directly tumoricidal,but rather indirectly mediate anti-tumor effects by inducing T cell activation mechanisms.

中文解释

免疫检查点抑制剂 (ICIs) 是一种单克隆抗体，可对抗称为检查点的免疫抑制途径。应用最广泛的 ICIs 是抗 CTLA-4、抗 Programmed death receptor 1 (PD-1) 和抗 Programmed cell death ligand 1 (PD-L1) 抗体。这些药物不被认为是直接杀伤肿瘤，而是通过诱导T细胞激活机制间接介导抗肿瘤作用。

参考文献

[1]. Hayase E, Jenq RR. Role of the intestinal microbiome and microbial-derived metabolites in immune checkpoint blockade immunotherapy of cancer. Genome Med. 2021 Jun 23;13(1):107.