Interleukin-1 receptor associated kinase 4 (IRAK4)

白细胞介素 1 受体相关激酶 4

英文解释

Interleukin-1 receptor-associated kinase 4 (IRAK4) is the most upstream kinase in Toll/Interleukin-1 receptor (TIR) signaling. IRAK4 also take part in TIR signaling with IRAK1, IRAK2, and IRAK3 (also called IRAKM) together. IRAK4 can be used for the research of immune response.

中文解释

白细胞介素 1 受体相关激酶 4 (IRAK4) 是 Toll/白细胞介素 1 受体 (TIR) 信号传导中最上游的激酶。IRAK4 还与 IRAK1、IRAK2 和 IRAK3 (IRAKM) 一起参与 TIR 信号传导。IRAK4可用于免疫反应的研究。

参考文献

[1]. William T McElroy, et al. Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors: an updated patent review (2016-2018). Expert Opin Ther Pat. 2019 Apr;29(4):243-259.