Ionic gradient liposomes (IGL)

离子梯度脂质体

英文解释

Ionic gradient liposomes (IGL) is a pharmaceutical carrier. IGL utilizes ion gradient for drug encapsulation, necessitates active loading of the drug in preformed vesicles exhibiting a transmembrane pH or ion gradient, with a low intra liposome pH, and a high outside pH. IGL allows high drug encapsulation and prolonged release.

中文解释

离子梯度脂质体 (IGL) 是一种药物载体。IGL 利用离子梯度进行药物包封，需要将药物主动加载到呈现跨膜 pH 或离子梯度、脂质体内 pH 值低和外部 pH 值高的预制囊泡中。IGL 允许高药物封装和延长释放。

参考文献

[1]. Munazza Tamkeen Fatima, et al. Ionic gradient liposomes: Recent advances in the stable entrapment and prolonged released of local anesthetics and anticancer drugs. Biomed Pharmacother. 2018 Nov;107:34-43.