JAK/STAT pathway

JAK/STAT 通路

英文解释

JAK/STAT pathway is the pathway of Signal transducer and activator of transcription (STAT) is phosphorylated by Janus kinase (JAK), dimerized, and then transports into the nucleus through the nuclear membrane to regulate the expression of related genes. JAK/STAT pathway is one of the most important signaling pathways, directly regulates the communication from transmembrane receptors to the nucleus.

中文解释

JAK/STAT 通路是信号转导和转录激活因子 Signal transducer and activator of transcription (STAT) 被 Janus 激酶 Janus kinase (JAK) 磷酸化，二聚化，然后通过核膜运输到细胞核，调节相关基因的表达的途径。JAK/STAT 通路是最重要的信号通路之一，直接调控跨膜受体到细胞核的通信。

参考文献

[1]. Xin P, et al. The role of JAK/STAT signaling pathway and its inhibitors in diseases. Int Immunopharmacol. 2020 Mar;80:106210.