Langerhanscellhistiocytosis (LCH)

朗格汉斯细胞组织细胞增生症

英文解释

Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells driven by mutations in the mitogen-activated protein kinase pathway. LCH is a rare systemic disorder characterized by the accumulation of CD1a+/Langerin+ LCH cells and wide-ranging organ involvement.

中文解释

朗格汉斯细胞组织细胞增生症 (LCH) 是一种由丝裂原活化蛋白激酶通路突变驱动的骨髓前体细胞炎性肿瘤。LCH 是一种罕见的全身性疾病，其特征是 CD1a+/Langerin+ LCH 细胞的积累和广泛的器官受累。

参考文献

[1]. Jolie Krooks, et al. Langerhans cell histiocytosis in children: History, classification, pathobiology, clinical manifestations, and prognosis. J Am Acad Dermatol. 2018 Jun;78(6):1035-1044.
[2]. Masayuki Kobayashi, et al. Langerhans cellhistiocytosis in adults: Advances in pathophysiology and treatment. Cancer Sci.2018 Dec;109(12):3707-3713.