Lipoxygenases (LOXs)

脂氧合酶

英文解释

Lipoxygenase are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. LOX enzymes are expressed in immune, epithelial, and tumor cells that display a variety of physiological functions, including inflammation, skin disorder, and tumorigenesis. In the humans and mice, six LOX isoforms have been known.

中文解释

脂氧合酶 是双加氧酶，可催化多不饱和脂肪酸（例如亚油酸和花生四烯酸）形成相应的氢过氧化物。LOX 酶在免疫细胞、上皮细胞和肿瘤细胞中表达，这些细胞表现出多种生理功能，包括炎症、皮肤病和肿瘤发生。在人类和小鼠中，已知有六种 LOX 亚型。

参考文献

[1]. Ryuichi Mashima, et al. The role of lipoxygenases in pathophysiology; new insights and future perspectives. Redox Biol. 2015 Dec;6:297-310.