Lysine specific demethylase 1 (LSD1)

赖氨酸特异性脱甲基酶 1

英文解释

Lysine-specific demethylase 1(LSD1) also known as KDM1A, is the first discovered histone lysine demethylase. LSD1 has the ability to demethylase H3K4me1/2 and H3K9me1/2 at target loci in a context-dependent manner. LSD1 regulates the balance between self-renewal and differentiation of stem cells. LSD1 is highly expressed in various cancers and mediates differentiation and self-renewal of tumor cells.

中文解释

赖氨酸特异性脱甲基酶 1 (LSD1) 也称为 KDM1A，是第一个被发现的组蛋白赖氨酸脱甲基酶。LSD1 能够在目标位点对 H3K4me1/2 和 H3K9me1/2 进行去甲基化。LSD1 调节干细胞自我更新和分化之间的平衡。LSD1 在多种癌症中高表达，并介导肿瘤细胞的分化和自我更新。

参考文献

[1]. Hosseini A, et al. A comprehensive review of lysine-specific demethylase 1 and its roles in cancer. Epigenomics. 2017 Aug;9(8):1123-1142.