Mitochondria-associated ER membrane (MAM)

线粒体相关 ER 膜

英文解释

Mitochondria-associated ER membrane (MAM) is a functional subdomain of the endoplasmic reticulum membrane that tethers to the mitochondrial outer membrane and is essential for cellular homeostasis. MAM disruption is a common pathological feature in amyotrophic lateral sclerosis.

中文解释

线粒体相关 ER 膜 (MAM) 是内质网膜的一个功能子域，它与线粒体外膜相连，对细胞稳态至关重要。MAM 破坏是肌萎缩侧索硬化症的常见病理特征。

参考文献

[1]. Sakai S, et al. Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis. FASEB J. 2021 Jul;35(7):e21688.