Mitogen-activated protein (MEK)

丝裂原活化蛋白

英文解释

Mitogen-activated protein (MEK) is a kinase enzyme which phosphorylates mitogen-activated protein kinases (MAPKs). The activated MAPK leads to the phosphorylation of downstream transcription factors that regulate various responses such as stress signaling, pathogen response, and hormone signaling. MEK is essential for signaling of various extracellular stimuli to the nucleus.

中文解释

丝裂原活化蛋白 是磷酸化有丝分裂原活化蛋白激酶 (MAPK) 的激酶。激活的 MAPK 导致下游转录因子磷酸化，这些转录因子调节各种反应，如应激信号、病原体反应和激素信号。MEK 对于向细胞核发出各种细胞外刺激信号至关重要。

参考文献

[1]. Fukuda M, et al. Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J. 1997 Apr 15;16(8):1901-8.