Mitogen-activated protein kinases (MAPKs)

丝裂原激活蛋白激酶

英文解释

Mitogen-activated protein kinases (MAPKs) are involved in signaling processes induced by various stimuli, such as growth factors, stress, or even autoantibodies. MAPKs comprise three functional families, namely, Extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK)and p38. MAPK signaling thus provides a versatile signaling module that regulates cell proliferation, differentiation, homeostasis and even cell.

中文解释

丝裂原激活蛋白激酶 (MAPKs) 参与由各种刺激诱导的信号传递过程，如生长因子，应激，甚至自身抗体。MAPKs 包括三个功能家族，即 Extracellular signal-regulated kinases (ERKs)、c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) 和 p38。因此，MAPK 信号提供了一个多功能的信号模块，调节细胞增殖、分化、稳态甚至细胞死亡。

参考文献

[1]. Tikkanen R, Nikolic-Paterson DJ. Mitogen-Activated Protein Kinases: Functions in Signal Transduction and Human Diseases. Int J Mol Sci. 2019 Sep 29;20(19):4844.