Mixed lineage leukemia protein-1 (MLL1) (also called MLL/KMT2A/HRX/HTRX/ALL1)

混合谱系白血病蛋白 1

英文解释

Mixed lineage leukemia protein-1 (MLL1), a histone methyltransferase and transcription factor, is critical for epigenetic maintenance of Hox gene expression, and is required for normal fetal and adult hematopoiesis. MLL1 is located at chromosome 11q23 which cause acute leukemia.

中文解释

混合谱系白血病蛋白 1 (MLL1) 是一种组蛋白甲基转移酶和转录因子，对于 Hox 基因表达的表观遗传维持至关重要，并且是正常胎儿和成人造血所必需的。MLL1 位于引起急性白血病的染色体 11q23。

参考文献

[1]. Xu J, et al. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program. Cell Discov. 2016 May 17;2:16008.
[2]. Li X, et al. Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins. J Hematol Oncol. 2021 Apr 6;14(1):56.