Multidrug-resistant (MDR)

耐多药

英文解释

Multidrug-resistant (MDR) refers to a situation in which the disease becomes resistant to drug treatment, and once resistance develops, the effect of the drug is significantly reduced or no longer works at all. When an organism develops resistance to multiple drugs, it is called multidrug-resistant (MDR). Resistance results from kinase mutations that interfere with inhibitor binding without compromising kinase function.

中文解释

耐多药 (MDR) 是指一种疾病对药物治疗产生耐药性的情况。 一旦出现耐药性，药物的作用就会显着降低或根本不再起作用。当生物体对多种药物产生抗药性时，称为耐多药 MDR。耐药是由于激酶突变干扰抑制剂结合而不影响激酶功能。

参考文献

[1]. Priya Kannian, et al. Carbapenem-Resistant Gram Negative Bacilli Are Predominantly Multidrug or Pan-Drug Resistant. Microb Drug Resist. 2021 Aug;27(8):1057-1062.
[2]. Ralph Tiedt, et al. A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. Cancer Res. 2011 Aug 1;71(15):5255-64.